Diet-induced obesity has become a worldwide epidemic, with almost 40% of the adult population being overweight or obese. This disease increases mortality, as well as the susceptibility to suffer from more than one disorder at the same time. In addition, it is closely related to the risk of developing cancer. To date, much of the mechanisms involved in the harmful effects of obesity remain unknown, which makes it difficult to have viable therapeutic strategies or develop new treatments to combat it. Our work reveals the existence of a regulatory circuit of the RNA translation process to proteins, directed by CPEB4, hitherto unknown," explains Fernández-Lobato. "This is an important novelty, since, to date, research has mainly focused on the previous step, that is, the synthesis of RNA from DNA. Thus, our results promote a paradigm shift towards translational control, which may open new avenues of research to develop better treatments against obesity".